| 发明名称 |
OLIGONUCLEOTIDE N3'->P5' THIOPHOSPHORAMIDATES: THEIR SYNTHESIS AND USE |
| 摘要 |
Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3'-NHP(O)(S-)O-5' linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucleotides were found to retain the high RNA binding affinity of the parent oligonucleotide N3'-> P5' phosphoramidates and to exhibit a much higher acid stability. |
| 申请公布号 |
KR20070112295(A) |
申请公布日期 |
2007.11.22 |
| 申请号 |
KR20077024593 |
申请日期 |
2007.10.25 |
| 申请人 |
GERON CORPORATION |
发明人 |
GRYAZNOV SERGEI;PONGRACZ KRISZTINA;MATRAY TRACEY |
| 分类号 |
C07H21/00;C12N15/09;A61K31/7125;A61K48/00;A61P31/12;A61P35/00;A61P43/00;C07H19/173;C07H21/04;C12N15/11;C12N15/113;C12Q1/68 |
主分类号 |
C07H21/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
