DIOXASPIROKETAL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USES THEREOF

摘要

The invention relates to dioxaspiroketal derivatives of formula (I): wher ein R, is selected from the group consisting of H, straight or branched chai n C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, cycloalkyl, heterocyclyl, phenyl , optionally para-, meta- or ortho-substituted with 0 to 3 substituent selec ted from halogen, -CN, -NH2, -OH, -NO2, COOR2, wherein R2 is selected from H and C1-C6 alkyl, n is 1 or 2, X is O or S, R1 is selected from H, OH, halog en, C1-C6 alkyl, C1-C6 alkoxy, COOR3, wherein R3 is selected from H and C1-C 6 alkyl, or physiologically acceptable salts thereof, process for preparatio n thereof, their uses in medical field, in particular as anti-tumour medicam ents.