PYRIDINYLPYRAZOLOPYRIMIDINONE DERIVATIVES AS PDE 7 INHIBITORS

摘要

To provide the compounds inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic disease, inflammatory disease or immunologic disease. The compound is pyridinylpyrazolo-pyrimidinone compound represented by the following formula (IA) or (IB): especially, R¹ is cyclohexyl or cycloheptyl group, R² is methyl; R³ is a group: -NR⁵R⁶ or -S(O)_0-2R⁸;hydrogen atom; nitro group; cyano group; a halogen atom; heteroaryl group; and R⁴ is methoxy or ethoxy group.