| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing a 1,2-disubstituted imidazole, with which formations of 1-position substituted and 2-position substituted imidazoles among by-products are controlled. SOLUTION: The method for producing a 1,2-disubstituted imidazole comprises reacting a reaction solution containing ammonia and a primary amine with an aldehyde compound and glyoxal. (1) The reaction solution is reacted with a part of the aldehyde compound to carry out a first-stage reaction, then the reaction system is reacted with the remaining aldehyde compound and glyoxal to carry out a second-stage reaction. Otherwise, (2) the reaction solution is mixed with a part of the aldehyde compound and a part of the glyoxal to carry out a first-stage reaction at 0-50°C and then the reaction system is mixed with the remaining aldehyde compound and the remaining glyoxal to carry out a second-stage reaction at a temperature 10-50°C higher than that of the first-stage reaction. COPYRIGHT: (C)2008,JPO&INPIT
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