| 摘要 |
An oral sustained release pharmaceutical composition comprising a plurality of granules having diameters of not more than 1000 mum, wherein each of the granules comprise a nucleus granule comprised of beraprost sodium and a coating agent coating the nucleus granule, and wherein the coating agent is comprised of a first skin layer containing one or more relatively water-insoluble macromolecular substances, and a second skin layer containing one or more hot-melt low-melting substances.
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