发明名称 |
Diagnostic and Therapeutic Use of the Human Dax-1 Gene and Protein for Neurodegenerative Diseases |
摘要 |
The present invention discloses the differential expression of a cytosolic sulfotransferase in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using a gene coding for DAX-1. A method of screening for modulating agents of neurodegenerative diseases and recombinant animal models are also disclosed.
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申请公布号 |
US2007271619(A1) |
申请公布日期 |
2007.11.22 |
申请号 |
US20040595619 |
申请日期 |
2004.10.28 |
申请人 |
VON DER KAMMER HEINZ;POHLNER JOHANNES;HESTERKAMP THOMAS;EBNETH ANDREAS |
发明人 |
VON DER KAMMER HEINZ;POHLNER JOHANNES;HESTERKAMP THOMAS;EBNETH ANDREAS |
分类号 |
A01K67/00;C07H21/00;C07K14/00;C12Q1/68;G01N33/00;G01N33/50;G01N33/53;G01N33/68 |
主分类号 |
A01K67/00 |
代理机构 |
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地址 |
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