The present invention is directed to intrauterine devices that release progestins or an inflammatory cytokine after placement. These devices can be used to reduce the risk of a woman developing endometrial cancer. The invention is also directed to therapeutic methods in which a sample of uterine cells obtained from a woman is assayed to determine the extent to which PTEN null clones (latent endometrial precancers) are present. In cases where the number of such null clones is high, the woman is administered an intrauterine device that releases either a progestin or an inflammatory cytokine.
申请公布号
WO2007089476(A3)
申请公布日期
2007.11.22
申请号
WO2007US01749
申请日期
2007.01.23
申请人
THE BRIGHAM & WOMEN'S HOSPITAL, INC.;MUTTER, GEORGE, L.;VISWANATHAN, AKILA, N.;ORBO, ANNA
发明人
MUTTER, GEORGE, L.;VISWANATHAN, AKILA, N.;ORBO, ANNA