HIGH THROUGHPUT SCREENING FOR ANTIMICROBIAL DOSING REGIMENS

摘要

Provided herein are methods and computer-implemented systems for using computer simulations to predict likelihood of a cell population associated with a pathophysiological condition acquiring resistance to a therapeutic agent, to screen fortherapeutic agents effective to suppress acquisition of resistance within a cell population and to treat the pathophysiological conditions associated therewith. The computer simulation comprises at least an input/out system and a mathematical model, including operably linked equations, parameter values and constant values, of growth response over a period of tune of a cell population in contact with an therapeutic agent.