PROCESS FOR PRODUCTION OF RADIOACTIVE FLUORINE-LABELED ORGANIC COMPOUND
摘要
[PROBLEMS] To provide a process for production of [<SUP>18</SUP>F]FACBC, which can reduce the amount of an impurity produced during the process. [MEANS FOR SOLVING PROBLEMS] A process for production of a radioactive fluorine-labeled organic compound, comprising the following steps: a deesterification step for retaining a compound represented by the formula (1) in a reverse-phase column, charging an alkaline solution into the column to deesterify the compound, and then discharging the alkaline solution from the column to produce a compound represented by the formula (2); and a deprotection step for deprotecting an amino-protecting group in the compound produced in the deesterification step to produce a compound represented by the formula (3). (1) [wherein R<SUP>1</SUP> represents a linear or branched alkyl chain having 1 to 10 carbon atoms or an aromatic substituent; and R<SUP>2</SUP> represents a protecting group.] (2) [wherein X represents sodium or potassium.] (3)