摘要 |
<p>The present invention concerns to the use of salicylate in the treatment of mammal intoxications caused by the herbicide paraquat (PQ). It was achieved, for the first time, 100% of survival 30 days after the administration to Wistar rats, by intraperitoneal route, of a PQ dose that, in the absence of treatment, is itself 100% lethal at the end of 6 days. The administration of salicylate, two hours after PQ, reversed the PQ toxicity and extended the life of the animals to the levels of the control group.</p> |
申请人 |
UNIVERSIDADE DO PORTO;DIAS CARVALHO, FELIX;DINIS OLIVEIRA, RICARDO JORGE;PINHO DE ALMEIDA SOUTEIRO BASTOS, MARIA DE LOURDES;GOMES REMIAO, FERNANDO MANUEL;RAMOS DUARTE, JOSE ALBERTO;SANCHEZ NAVARRO, AMPARO |
发明人 |
DIAS CARVALHO, FELIX;DINIS OLIVEIRA, RICARDO JORGE;PINHO DE ALMEIDA SOUTEIRO BASTOS, MARIA DE LOURDES;GOMES REMIAO, FERNANDO MANUEL;RAMOS DUARTE, JOSE ALBERTO;SANCHEZ NAVARRO, AMPARO |