| 摘要 |
The antibiotics tetracycline or chlortetracycline are produced by fermentation of a culture medium containing assimilable carbohydrates, organic nitrogen and mineral salts with a strain of Streptomyces lusitanus, especially S. Lusitanus CBS 101-A, under submerged aerobic conditions at a temperature of 24-30 DEG C. A specified culture medium contains starch, lardoil, peanut meal, calcium carbonate, ammonium sulphate, ammonium chloride and corn steep liquor. Chlortetracycline is produced when the culture medium contains chlorine ions and tetracycline when the culture medium is free of chlorine ions. The antibiotics may be isolated as their dibenzyl ethylene diamine complexes. Specifications 713,795 and 936,314 are referred to.
|
