METHOD FOR THE PRODUCTION OF ANTIBODIES IN IMMUNODEFICIENT ANIMAL INJECTED WITH HUMAN FETAL LIVER STEM CELLS
摘要
<p>The current invention is related to a method for the production of a human monoclonal antibody from an immundeficient non-human animal, said method comprising contacting a newborn immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non- human animal (reconstituted animal), subsequently contacting said reconstituted animal with an antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.</p>
申请公布号
WO2007131676(A1)
申请公布日期
2007.11.22
申请号
WO2007EP04085
申请日期
2007.05.09
申请人
F. HOFFMANN-LA ROCHE AG;LIFKE, ALEXANDER;LIFKE, VALERIA;MUELLER-BECKMANN, BERND;SCHNITZER, TOBIAS