发明名称 |
MAKERS FOR THE DIAGNOSIS OF SUSCEPTIBILITY TO LUNG CANCER USING CASPASE-9 GENE AND METHOD FOR PREDICTING AND ANALYZING SUSCEPTIBILITY TO LUNG CANCER USING THE SAME |
摘要 |
Makers for the diagnosis of susceptibility to lung cancer are provided to predict and analyze lung cancer susceptibility by using polymorphisms located at a promoter of a caspase-9(CASP-9) gene closely associated with susceptibility to lung cancer. A marker for the diagnosis of susceptibility to lung cancer is at least one polynucleotide selected from a polynucleotide of SEQ ID NO:1 comprising 20-100 consecutive DNA sequences containing a 242th base(-1263rd base from a transcription-starting point of CASP-9 gene) that is substituted from A to G, a polynucleotide of SEQ ID NO:1 comprising 20-100 consecutive DNA sequences containing a 793rd base(-712nd base from a transcription-starting point of CASP-9 gene) that is substituted from C to T, and a polynucleotide complementary therewith. A method for predicting and analyzing susceptibility to lung cancer comprises the steps of: (a) obtaining a nucleic acid sample from a testing specimen; (b) amplifying at least one polymorphism region selected from a 242nd base of SEQ ID NO:1, a 600th base of SEQ ID NO:1, a 793rd base of SEQ ID NO:1 and 1212nd-1230th bases of SEQ ID NO:1; and (c) determining the base in the amplified polymorphism region.
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申请公布号 |
KR20070111301(A) |
申请公布日期 |
2007.11.21 |
申请号 |
KR20060094914 |
申请日期 |
2006.09.28 |
申请人 |
KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION |
发明人 |
PARK, JAE YONG;KIM, IN SAN;LEE, MYUNG HOON |
分类号 |
C12N15/10;C12N15/09 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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地址 |
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