COMPOSITION FOR PREVENTING OR TREATING ATHEROSCLEROSIS, DEMENTIA, CANCER AND OXIDATIVE STRESS COMPRISING DAMMARANE TRITERPENES

摘要

A composition comprising dammarane triterpenes is provided to inhibit activity of ACAT(acyl-CoA:cholesterol acyltransferase), remove reactive oxygen species, peroxynitrite and hydrogen peroxide, suppress production of nitrogen oxide and kill cancer cells without side effects, thereby preventing or treating atherosclerosis, dementia, cancer and oxidative stress. A composition for preventing or treating atherosclerosis, dementia, cancer and oxidative stress comprises dammarane triterpenes isolated from Rhus chinensis Mill., including 20-hydroxy-24-dammaren-3-one represented by the formula(1), 3-hydroxy-3, 3-oxodammar-20, 24E-dien-26-oic acid represented by the formula(2) and 19-epoxydammar-20, 24-dien-22, 26-olide represented by the formula(3), which are isolated by extracting the stem of Rhus chinensis Mill. with methanol, fractionating the crude extract with ethylacetate and water, concentrating the fraction under reduced pressure, and subjecting the concentrate to silica gel column chromatography.