FUSED HETEROAROMATIC GLUCOKINASE ACTIVATORS

摘要

Glucokinase activating compounds or pharmaceutically acceptable salts of Formula I-0: (See formula I-0) wherein M is (See formula I) or (See formula II) Q is (See formula III) or (See formula IV) R1 is an alkyl having from 1 to 3 carbon atoms; R2 is hydrogen, halo, nitro, cyano, or perfluoro-methyl; R3 is a cycloalkyl having from 4 to 7 carbon atoms or 2- propyl; R5 is halogen; R6 is halogen; W is O, S or NH; each Y is independently CH or N; Z is CH2-CH2-CH2-CH2 or CH=CR4-CH=CH-, wherein R4 is hydrogen, halo, or an alkyl sulfone having from 1 to 3 carbon atoms; and dotted lines collectively represent O or 2 additional double bonds in the heterocyclic ring structure. Compounds of Formula 1-0 may be present either as a racemate or in the isolated "R" configuration at the asymmetric carbon shown.