发明名称 |
Intermediates and enzymes of the non-mevalonate isoprenoid pathway |
摘要 |
The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2-butenyl 4-diphosphate, notably in its (E)-form, to isopentenyl diphosphate and/or dimethylallyl diphosphate. Further, screening methods for inhibitors of these proteins are provided. Further, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate is provided and chemical and enzymatic methods of its preparation.
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申请公布号 |
US7297509(B2) |
申请公布日期 |
2007.11.20 |
申请号 |
US20040474536 |
申请日期 |
2004.04.07 |
申请人 |
BACHER ADELBERT;ROHDICH FELIX;ADAM PETRA;AMSLINGER SABINE;EISENREICH WOLFGANG;HECHT STEFAN |
发明人 |
BACHER ADELBERT;ROHDICH FELIX;ADAM PETRA;AMSLINGER SABINE;EISENREICH WOLFGANG;HECHT STEFAN |
分类号 |
G01N33/50;A61K31/663;A61P31/04;A61P37/02;A61P37/04;A61P43/00;C07B61/00;C07C33/025;C07C33/035;C07C47/263;C07F9/09;C07F9/113;C07H19/10;C07K16/44;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/02;C12N9/16;C12N9/88;C12N9/99;C12N15/09;C12N15/52;C12N15/55;C12P9/00;C12Q1/02;G01N33/15;G01N33/569 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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