| 摘要 |
FIELD: organic chemistry, medicine, endocrinology, biochemistry, pharmacy. ^ SUBSTANCE: invention relates to 5-substituted pyrazine or pyridine derivatives of the general formula (I): or their pharmaceutically acceptable salts wherein R1 means lower alkyl comprising from 1 to 5 carbon atoms; R2 means hydrogen atom or halogen atom; R3 means cycloalkyl comprising from 4 to 6 carbon atoms; Y means -CH or nitrogen atom (N); R4 means a substitute at position 5 of pyridine or pyrazine ring chosen from group comprising compounds of the following formulae: ^ ^ ^ ^ ^ ^ Compounds of the formula (I) are activators of glucokinase and can be used in treatment of diabetes mellitus of type II. Also, invention describes a pharmaceutical composition based on proposed compounds and their using in preparing a drug designated for treatment of diabetes mellitus of type II. ^ EFFECT: valuable medicinal properties of compounds. ^ 78 cl, 86 ex |
