Anti-cancer cyclopenta [G]quinazoline compounds

摘要

Cyclopenta[g]quinazolines of the formula (I):-wherein: A is a group OR or NR⁰R¹ wherein R⁰ and R¹ are each independently hydrogen C_1-4 alkyl, C_3-4 alkenyl, C_3-4 alkynyl, C_2-4 hydroxyalkyl, C_2-4 halogenoalkyl or C_1-4 cyanoalkyl, or R⁰ and R¹ together with the intermediate N form a five- or six-membered heterocyclic ring, p is an integer in the range 1 to 4, R² is hydrogen, C_1-4 alkyl, C_3-4 alkenyl, C_3-4 alkynyl, C_2-4 hydroxyalkyl, C_2-4 halogenoalkyl or C_1-4 cyanoalkyl; Ar¹ is phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl which may optionally bear one or two substituents selected from halogeno, hydroxy, amino, nitro, cyano, trifluoromethyl, C_1-4 alkyl and C_1-4 alkoxy, and R³ is a group of one of the following formulae: -A¹-Ar²-A²-Y¹-A⁵-CON(R)CH(Y⁴)Y⁵-A⁸-X-Ar⁴ and pharmaceutically acceptable salts or esters thereof are of therapeutic value particularly in the treatment of cancer