POLYETHYLENE GLYCOL-INTERFERON ALPHA CONJUGATE

摘要

A polyethylene glycol-interferon alpha conjugate is provided to increase half-life of the interferon alpha in blood by minimizing physiological activity reduction of interferon alpha, and improve purity and production yield of the conjugate, thereby efficiently showing antiviral and anticancer activity of the conjugate. A conjugate of tri-branched polyethylene glycol having the average molecular weight of 400-45,000 dalton, and being represented by the formula(1) and interferon alpha has the antiviral and anticancer activity, wherein n is an integer from 1 to 1,000 and m is an integer from 10 to 1,000; Z is a linker between interferon alpha and polyethylene glycol and is alkylene group of (CH2)s or (CH2)sNHCO(CH2)s in which S is an integer from 1 to 6; and Y is an amide bond or a secondary amine structure produced by bonding a NH2 group in the interferon molecule with functional groups of polyethylene glycol derivatives.