ANTIBIOTICS AND METHODS FOR PRODUCING THEM.

摘要

The invention relates to cyclic peptides and methods for producing and using them. Provided is amongst others a method for determining whether a compound comprises antibiotic activity, the method comprising providing a cyclic peptide to a bacterium wherein a 23S rRNA in a 5OS ribosomal subunit does not comprises a 2' O-methylation at a nucleotide that corresponds to nucleotide C 1920 in E. coli and determining whether said compound inhibits growth of said first bacterium.