| 摘要 |
The invention relates to compounds of the formula I, or pharmaceutically acceptable salts thereof: wherein: Z=O or S; n=1-3; R--CO<SUB>2</SUB>R<SUP>8</SUP>, -C(O)SR<SUP>8</SUP>, -C(O)NHR<SUP>8</SUP>, -C(S)OR<SUP>8</SUP>, -C(S)SR<SUP>8</SUP>, -C(S)NHR<SUP>8</SUP>, -C(NH)SR<SUP>8 </SUP>or -C(NH)NR<SUP>8</SUP>, wherein R<SUP>8 </SUP>is -H or alkyl; R<SUP>4</SUP>-.H, -CH<SUB>2</SUB>R<SUP>5 </SUP>or -CH<SUB>2</SUB>CH<SUB>2</SUB>R<SUP>5</SUP>, wherein R<SUP>5 </SUP>independently has one of the meanings of R<SUP>3</SUP>; B--NR<SUP>2</SUP>-, -CH<SUB>2</SUB>NR<SUP>2</SUP>-, -CH<SUB>2</SUB>CH<SUB>2</SUB>NR<SUP>2</SUP>, -CH<SUB>2</SUB>CHR<SUP>2</SUP>- or -CH<SUB>2</SUB>O-, wherein R<SUP>2 </SUP>is H or a C<SUB>1 3 </SUB>alkyl, alkenyl or alkynyl group, and R<SUP>7 </SUP>is H or a C<SUB>13 </SUB>alkyl or alkoxy group; A=wherein R<SUP>1</SUP>--NH<SUB>2 </SUB>or -OH, and C and D are each, independently, a 5 - or 6 -membered, substituted or unsubstituted, aromatic or non-aromatic ring which may also contain one or more heteroatoms, and C is connected to group B in any available position.
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