| 摘要 |
The present invention relates to 17-oxymacbecin analogues according to th e formula (IA) or (IB) below, or a pharmaceutically acceptable salt thereof, wherein: R1 represents H, OH or OCH3; R2 represents H or CH3 R3 represents H or CONH2 R4 and R5 either both represent H or together they represent a bo nd (i.e. C4 to C5 is a double bond); and R6 represents H or OH; and R7 repre sents H or CH3. that are useful, e.g. in the treatment of cancer, B-cell mal ignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimm une diseases and/or as a prophylactic pretreatment for cancer. The present i nvention also provides methods for the production of these compounds and the ir use in medicine, in particular in the treatment and / or prophylaxis of c ancer or B-cell malignancies.
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