发明名称 NOVEL SALT OF QUINUCLIDINE DERIVATIVE
摘要 An acid addition salt formed from (-)-(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid (3R)-quinuclidin-3-yl ester and an acid selected from the group consisting of (-)-(2S,3S)-tartaric acid, (+)-(2S,3S)-di-o-benzoyltartaric acid, (+)-(2S,3S)-di-o-(4-methylbenzoyl) tartaric acid, (-)-L-phenylalanine, benzenesulfonic acid, cyclohexanesulfamic acid, hydrobromic acid, naphthalene-2-sulfonic acid, sebacic acid, (+)-camphor-10-sulfonic acid, p-toluenesulfonic acid, ethanesulfonic acid, methanesulfonic acid and methyl phosphate. This salt does not show hygroscopicity in such a level that is not desirable for use as a pharmaceutical agent or an active ingredient of a pharmaceutical agent, and therefore is an extremely useful compound for use as a pharmaceutical agent or an active ingredient of a pharmaceutical agent.
申请公布号 KR20070110128(A) 申请公布日期 2007.11.15
申请号 KR20077022738 申请日期 2007.10.05
申请人 ASTELLAS PHARMA INC. 发明人 HAYAKAWA MASAHIKO;SAMIZU KIYOHIRO;UEBAYASHI HIROSHI;IKEDA KEN;TAKEUCHI MAKOTO
分类号 C07D453/02;A61K31/435;A61K31/439;A61K31/4725;A61P1/00;A61P1/04;A61P1/06;A61P7/12;A61P11/00;A61P11/06;A61P11/08;A61P13/00;A61P25/00;A61P27/16 主分类号 C07D453/02
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