MAMMALIAN OBESTATIN RECEPTORS

摘要

A high affinity obestatin receptor GPR39 is provided which mediates obestatin activities. The obestatin receptor (GPR39) and fragments thereof, particularly soluble fragments thereof, are useful as therapeutic agents capable of inhibiting the action of obestatin. Screening and research methods for the determination of specific analogs, agonists, antagonist mimetics and agents that modulate production, metabolism, and disposition of GPR39 activities are disclosed. Conditions treatable with GPR39 agonists or antagonists include regulation of weight, blood pressure, heart rate and gastric empyting.