COMPOSITIONS AND METHODS FOR HIGH THROUGHPUT SCREENING OF PHARMACOLOGICAL CHAPERONES
摘要
Assays are provided for the screening and classification of biologically active agents that alter the conformation of conformationally defective proteins. The methods of the invention find use in the identification and classification of agents with chaperone activity, particularly the identification and classification of small molecule chemical and pharmacological chaperones. The agents thus identified find use altering the conformation of otherwise conformationally defective proteins.
申请公布号
WO2007089591(A3)
申请公布日期
2007.11.15
申请号
WO2007US02181
申请日期
2007.01.26
申请人
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;KOPITO, RON R.;ZHANG, WEI