| 摘要 |
PROBLEM TO BE SOLVED: To provide a modified recombinant virus of improved safety and to provide a method for producing such recombinant virus. SOLUTION: A recombinant virus which is a modified recombinant virus which has improved safety because its toxicity is attenuated by the inactivation of the gene function encoded by the virus is produced. The gene function is nonessential and is associated with toxicity. As the virus, a poxvirus is advantageous, and it is especially vacciniavirus or avipoxvirus. The modified recombinant virus may contain in its non-essential region of the virus genome a foreign DNA sequence which codes for immunodeficiency virus-derived antigen, epitope and/or CTL epitope, such as HIV1gag (+pro)(IIIB), gp120(MN)(+transmembrane), nef(BRU)CTL, pol(IIIB)CTL, ELDKWA, or LDKW epitope, or the like. COPYRIGHT: (C)2008,JPO&INPIT
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