发明名称 |
SPHINGOID POLYALKLAMINE CONJUGATES, ISOMERS AND USES THEREOF |
摘要 |
The present application discloses methods for stimulating or enhancing an immune response of a subject to protect against an infection caused by an agent selected from Hepatitis B Virus (HBV), avian influenza virus, the bacterium Bacillus anthracis or the bacterium Streptococcus pneumoniae, the method comprising administering to said subject a combination of sphingoid-polyalkylamine conjugate and a biologically active molecule, the combination being effective to provide said stimulation or enhancement of the immune response. Also disclosed are vaccines comprising a combination of the sphingoid-polyalkylamine conjugate and a biologically active molecule for stimulating or enhancing an immune response of a subject to protect against an infection caused by such an agent. Preferred conjugates are N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine (C-1 CCS), N-palmitoyl D-erythro sphingosyl-3-carbamoyl spermine (C-3 CCS) and mixtures thereof. Also disclosed are uses of C-3 CCS for various applications.
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申请公布号 |
US2007264273(A1) |
申请公布日期 |
2007.11.15 |
申请号 |
US20070746415 |
申请日期 |
2007.05.09 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM;BIOLAB LTD.;NASVAX LTD. |
发明人 |
BARENHOLZ YECHEZKEL;KEDAR ELIEZER;SAMIRA SARIT |
分类号 |
A61K39/00;A61K31/132;A61K38/47;A61K39/08;A61K39/145;A61K39/29;A61K39/39;A61K48/00;A61P37/02;A61P43/00;C07C271/20 |
主分类号 |
A61K39/00 |
代理机构 |
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地址 |
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