| 摘要 |
PROBLEM TO BE SOLVED: To provide a new method for producing a 1-alkoxy-5-hydroxyisoquinoline derivative or its hydrate useful as a production intermediate for 4-(4-dialkylaminomethyl)phenyl-5-hydroxy-1-isoquinoline derivative having excellent PARP inhibiting activity and under development as a promising medicine. SOLUTION: A 1-alkoxy-5-hydroxyisoquinoline derivative expressed by general formula (IV) or its hydrate is produced by reacting an isoquinoline N-oxide derivative expressed by general formula (I) with an acylating agent or a sulfonating agent expressed by general formula (II) and an alcohol expressed by general formula (III). COPYRIGHT: (C)2008,JPO&INPIT
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