NOVEL COMPOUNDS

摘要

The present invention relates to 18,21-didesoxymacbecin analogues that ar e useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fun gal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular, in the treatment and/or prophylaxis of cancer or B-cell maligna ncies. Formula (I) wherein: R1 represents H, OH, OMe; R2 represents H or Me; R3 represents H or CONH2; R4 and R5 either both represent H or together the y represent a bond (i.e. C4 to C5 is a double bond); R6 represents H or F; R 7 represents H or F; and R8 represents H or F.