发明名称 |
Methods for producing L-lysine and L-glutamic acid by fermentation |
摘要 |
A mutant strain having an ability to produce L-glutamic acid in the absence of any biotin action-suppressing agent in a medium containing an excessive amount of biotin is obtained by giving temperature sensitivity to a biotin action-suppressing agent to a coryneform L-glutamic acid-producing bacterium. This strain is cultivated in a liquid medium to produce and accumulate L-glutamic acid in the medium. A mutant strain having an ability to produce L-lysine and L-glutamic acid in the absence of any biotin action-suppressing agent in a medium containing an excessive amount of biotin is obtained by giving temperature sensitivity to a biotin action-suppressing agent and L-lysine productivity to a coryneform L-glutamic acid-producing bacterium. This strain is cultivated in a liquid medium to simultaneously produce and accumulate L-lysine and L-glutamic acid in the medium. |
申请公布号 |
EP1293560(B1) |
申请公布日期 |
2007.11.14 |
申请号 |
EP20020025583 |
申请日期 |
1995.08.09 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
KIMURA, EIICHIRO;ASAKURA, YOKO;UEHARA, AKINORI;INOUE, SUMIO;KAWAHARA, YOSHIO;YOSHIHARA, YASUHIKO;NAKAMATSU, TSUYOSHI |
分类号 |
C12P13/08;C12N1/20;C12N1/21;C12N15/03;C12N15/09;C12P13/14;C12R1/15 |
主分类号 |
C12P13/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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