MEANS AND METHODS FOR MODIFYING GENE EXPRESSION USING UNPOLYADENYLATED RNA

摘要

Methods and means are provided for reducing expressing of a nucleic acid of interest, thereby altering the phenotype of an animal cell, by providing aberrant, preferably unpolyadenylated, target specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-specific RNA is provided by expression of a chimeric DNA construct comprising a promoter