Anthranyl derivatives having an anticholecystokinin activity (anti-cck-1), a process for their preparation, and pharmaceutical use thereof

摘要

Anthranylic compounds having anti-CCK activity of general formula (I) in which, n is a whole number lying between 0 and 7; R₁ is chosen independently from the groups (II), in which X₁ is chosen independently from, S, O, NR₂ and X₂ is a group chosen from: H, C₁-C₄ alkyl, F, Cl, CF₃, OCH₃, OC₂H₅, CN; R₂ is chosen from H or CH₃; R₃ is chosen from H, CH₃, F, Cl, CF₃, OCH₃; R₄ is chosen from the groups: H, -S-(CH₂)m-R₅, -SO₂-(CH₂)m-R₅ (n different from 0), a branched alkyl group, a cyclo alkyl, a cyclo alkenyl, the group 1 or 2 adamantile, a phenyl group optionally substituted; R₅ is chosen from the groups: H, linear or branched alkyl, cyclo alkyl, the group 1 or 2 adamantile, a suitably substituted phenyl group