| 摘要 |
FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention relates to chemistry of adamantine derivatives, namely, to a novel method for synthesis of (adamant-1-ylmethylene)-containing aromatic compounds of the general formula (I): , wherein R1 = R2 = R3 = R4 means hydrogen atom (H) (1); R1 means -CH3; R2 = R3 = R4 means H (2); R1 = R3 = R4 means H; R2 means -CH3 (3); R1 = R2 = R4 means H; R3 means -CH3 (4); R1 = R2 means H; R2 = R4 means -CH3 (5); R1 = R3 = R4 means -CH3; R2 means H (6); Ad means 1-adamantyl that are intermediate products for synthesis of biologically active substances. Method involves adding aromatic compounds to adamantine derivative wherein 1,3-dehydroadamantane is used as a adamantine derivative, and the following compounds are used as aromatic compounds: toluene, o-, m-, p-xylene, mesitylene, durene in the mole ratio of reagent = 1:(2-4) in the parent aromatic compound medium, at their boiling point (110-197°C) for 60 min. Invention provides simplifying method for synthesis of abovementioned compounds and their synthesis with higher yields. ^ EFFECT: improved methods of synthesis. ^ 6 ex |
