| 摘要 |
FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention relates to an improved method for synthesis of 3,5-dimethyladamantyl-1-amine or its salts. Method involves the bromination step of 1,3-dimethyladamantane with liquid bromine at boiling. The bromination reaction is carried out in the mole ratio 1,3-dimethyladamantane to bromine = 1:(2-8) but preferably in the ratio = 1:(3-6), and separation of bromine is carried out by distillation. Then the excessive amount of formamide is added to a synthesized residue and kept the mixture at temperature 120-180°C but preferably at 150-160°C. The end product is isolated in free form or as a salt. Proposed method allows simplifying the process based on decreasing non-utilizable waste and possibility for carrying out the process in a single apparatus to yield the end product of high quality and purity. ^ EFFECT: improved method of synthesis. ^ 3 cl, 11 ex |
