发明名称 METHODS FOR ACTIVATION OF CELLS-PRECURSORS/STEM CELLS
摘要 FIELD: medicine, chemical-pharmaceutical industry, pharmacy. ^ SUBSTANCE: invention relates to using compound of the formula Z-linker-Z' (1) representing antagonist of chemokinine receptor CXCR4 for preparing a medicinal agent used in mobilization and collection of cell-precursors and/or stem cells in subject. The claimed invention describes also methods for increasing amount of cell-precursors and stem cells in animals using compounds that bind chemokinine receptor CXCR4. Using compound of the formula (1) allows enhancing effectiveness in treatment of HIV and to alleviate unfavorable effects on bone marrow in the process of chemotherapy carrying out. ^ EFFECT: improved methods for activation. ^ 19 cl, 12 tbl, 1 dwg, 4 ex
申请公布号 RU2309741(C2) 申请公布日期 2007.11.10
申请号 RU20040105961 申请日期 2002.07.30
申请人 ANORMED INK. 发明人 BRIDZHER GARI DZH.;EHBRAMS MAJKL DZH.;KHENSON DZHEFFRI V.;MAKFARLEHND RONAL'D TREVOR;KALANDRA GARI B.;DEJL DEVID S.;BROKSMEJER KHEL EH.
分类号 A61K31/395;A61K45/00;A61K;A61K31/33;A61K31/496;A61K31/55;A61K31/551;A61K31/555;A61K35/14;A61K35/28;A61K38/00;A61K38/19;A61P7/00;A61P7/06;A61P17/02;A61P31/04;A61P35/02;A61P37/00;A61P37/04 主分类号 A61K31/395
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