发明名称 PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLOSPORINS
摘要 Pharmaceutical compositions comprising cyclosporines are provided to increase bioavailability of cyclosporins, reduce change rate of bioavailability in a patient for a long period, and inhibit influence by materials such as bile acid salt present in the gastrointestinal system. An oral pharmaceutical composition for cyclosporine therapy comprises 5-25 wt.% of cyclosporine A, 0.5-90 wt.% of hydrophilic components excluding lower C1-5 alkanol and 1,2-propyleneglycol, 0.5-90 wt.% of triglyceride lipophilic components and 0.5-90 wt.% of polyoxyethylene glycolated natural or hydrogenated vegetable oil surfactant, wherein the composition spontaneously forms oil-in-water(O/W) type microemulsion having particle size of 2,000 angstrom or less when it is diluted with water.
申请公布号 KR20070108289(A) 申请公布日期 2007.11.09
申请号 KR19990035661 申请日期 1999.08.26
申请人 NOVARTIS AG 发明人 HAUER BIRGIT;MEINZER ARMIN;POSANSKI ULRICH;RICHTER FRIEDRICH
分类号 A61K38/13;A61K;A61K9/107;A61K9/48;A61K38/00;A61K45/08;A61K47/08;A61K47/10;A61K47/14;A61K47/34 主分类号 A61K38/13
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