发明名称 |
Hydroxybenzamide Derivatives And Their Use As Inhibitors Of HSP90 |
摘要 |
The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R<SUP>1 </SUP>is hydroxy or hydrogen; R<SUP>2 </SUP>is hydroxy; methoxy or hydrogen; provided that at least one of R<SUP>1 </SUP>and R<SUP>2 </SUP>is hydroxy; R<SUP>3 </SUP>is selected from hydrogen; halogen; cyano; optionally substituted C<SUB>1-5 </SUB>hydrocarbyl and optionally substituted C<SUB>1-5 </SUB>hydrocarbyloxy; R<SUP>4 </SUP>is selected from hydrogen; a group -(O)<SUB>n</SUB>-R<SUP>7 </SUP>where n is 0 or 1 and R<SUP>7 </SUP>is an optionally substituted acyclic C<SUB>1-5 </SUB>hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C<SUB>1-5 </SUB>hydrocarbyl-amino; or R<SUP>3 </SUP>and R<SUP>4 </SUP>together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR<SUP>5</SUP>R<SUP>6 </SUP>forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.
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申请公布号 |
US2007259871(A1) |
申请公布日期 |
2007.11.08 |
申请号 |
US20070680830 |
申请日期 |
2007.03.01 |
申请人 |
ASTEX THERAPEUTICS LIMITED |
发明人 |
CHESSARI GIANNI;CARR MARIA G.;CONGREVE MILES S.;DOWNHAM ROBERT;FREDERICKSON MARTYN;MURRAY CHRISTOPHER W.;NAVARRO EVA F.;O'BRIEN MICHAEL A.;PHILLIPS THERESA R.;WOODHEAD ANDREW J.;WOOLFORD ALISON J. |
分类号 |
A61K31/4035;A61K31/47;A61K31/496;A61K31/5377;A61P35/00;C07D209/04;C07D215/00;C07D217/00;C07D227/00;C07D241/00;C07D265/30;C07D401/02;C07D471/00 |
主分类号 |
A61K31/4035 |
代理机构 |
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代理人 |
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地址 |
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