Acyclic 1,3-Diamine And Uses Therefor

摘要

This invention relates to novel compounds useful in the treatment of diseases associated with TRPV4 channel receptor. More specifically, this invention relates to certain substituted amino-azepines, according to Formula I or pharmaceutically acceptable salts, hydrates, or solvates thereof, wherein: R¹ is aryl optionally substituted with CN, NO₂, halogen or H; R² is H, C₁-C₆ alkyl, C₃-C₇ cycloalkyl, or C₃-C₇ heterocycloalkyl; R³ is H, OH, O-C₁-C₆ alkyl, SH, S-C₁-C₆ alkyl, or F; R⁴ is H, C₁-C₆ alkyl R⁵ is iso-butyl, cyclohexylmethyl, or cyclopentylmethyl; and R⁶ is aryl, heteroaryl.