发明名称 |
Verfahren und Mikroorganismus zur Herstellung von Purin-Nukleosiden durch Fermentation |
摘要 |
A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated repressor of purine nucleotide biosynthesis encoded by purR, a gene encoding an enzyme which is inactivated purine nucleoside phosphorylase encoded by deoD, a gene encoding an enzyme which is inactivated succinyl-AMP synthase encoded by purA, a gene encoding an enzyme which is inactivated 6-phosphogluconate dehydrase encoded by edd, a gene encoding an enzyme which is inactivated phosphoglucose isomerase encoded by pgi and like is bred and a purine nucleoside is produced by culturing the microorganism. |
申请公布号 |
DE69837041(T2) |
申请公布日期 |
2007.11.08 |
申请号 |
DE1998637041T |
申请日期 |
1998.07.17 |
申请人 |
AJINOMOTO CO. INC. |
发明人 |
MATSUI, HIROSHI;KAWASAKI, HISASHI;SHIMAOKA, MEGUMI;TAKENAKA, YASUHIRO;KURAHASHI, OSAMU |
分类号 |
C12N15/09;C12N1/21;C12P19/32;C12P19/40;C12R1/19 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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