发明名称 |
LIVE ATTENUATED BACTERIAL VACCINE TO REDUCE OR INHIBIT CARRIAGE AND SHEDDING OF ENTEROHEMORRHAGIC ESCHERICHIA COLI IN CATTLE |
摘要 |
The invention provides live, attenuated enterohemorrhagic Escherichia coli (EHEC) bacteria in which the Shiga toxin coding sequences are deleted to abolish Shiga toxin production and one or more of the nucleotide sequences for the bacterial adhesin protein intimin, the locus of enterocyte effacement encoded regulator, and the translocated intimin receptor are mutated to inactivate the activity of the encoded protein(s). This live, attenuated E. coli bacteria is used in a vaccine for reducing or inhibiting carriage and shedding of EHEC in cattle. |
申请公布号 |
WO2006047517(A3) |
申请公布日期 |
2007.11.08 |
申请号 |
WO2005US38364 |
申请日期 |
2005.10.26 |
申请人 |
UNIVERSITY OF MARYLAND BALTIMORE;ZHU, CHENGRU;BOEDEKER, EDGAR |
发明人 |
ZHU, CHENGRU;BOEDEKER, EDGAR |
分类号 |
A61K39/02;A01N63/00;A61K39/00;A61K39/108 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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