PERFORATED SUBMUCOSAL TISSUE GRAFT CONSTRUCTS

摘要

PROBLEM TO BE SOLVED: To provide a perforated unitary multi-laminar tissue graft construct and a method for preparing such construct.

SOLUTION: This method includes: a step of overlapping strips of submucosa tissue with other strips of submucosal tissue; a step of compressing at least the overlapped portions of the strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets; and a step of perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.

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