摘要 |
The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A-O-(CHR<SUP>1</SUP>CHR<SUP>2</SUP>O)<SUB>n</SUB>-B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [-CH(CH<SUB>3</SUB>)-COO-] and (ii) glycolide units [-CH<SUB>2</SUB>-COO-] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C<SUB>1-6</SUB>-alkyl or hydroxy protecting groups, one of R<SUP>1</SUP> and R<SUP>2</SUP> is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [-(CHR<SUP>1</SUP>CHR<SUP>2</SUP>O)-] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol. |
申请人 |
COLOPLAST A/S;VANGE, JAKOB;SCHWACH-ABDELLAOUI, KHADIJA;EVERLAND, HANNE;NIELSEN, PETER, SYLVEST;NIELSEN, BRIAN;JESPERSEN, LENE, KARIN;NIELSEN, LENE, FELDSKOV |
发明人 |
VANGE, JAKOB;SCHWACH-ABDELLAOUI, KHADIJA;EVERLAND, HANNE;NIELSEN, PETER, SYLVEST;NIELSEN, BRIAN;JESPERSEN, LENE, KARIN;NIELSEN, LENE, FELDSKOV |