| 发明名称 |
4,5-Dihydro-1H-pyrazole derivatives having potent CB1-antagonistic activity |
| 摘要 |
The present invention relates to a group of novel 4,5-dihydro-1H-pyrazole derivatives which are potent cannabinoid (CB<SUB>1</SUB>) receptor antagonists with utility for the treatment of diseases connected with disorders of the cannabinoid system. The compounds have the general formula (Ia) or (Ib) wherein the symbols have the meanings given in the specification. The invention also relates to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component. |
| 申请公布号 |
US2007259884(A1) |
申请公布日期 |
2007.11.08 |
| 申请号 |
US20050265090 |
申请日期 |
2005.11.03 |
| 申请人 |
SOLVAY PHARMACEUTICALS B.V. |
发明人 |
LANGE JOSEPHUS H.;KRUSE CORNELIS G.;TIPKER JACOBUS;VAN STUIVENBERG HERMAN H.;HERREMANS ARNOLDUS H. |
| 分类号 |
A61K31/415;C08K5/09;A61K31/194;A61K31/4155;A61K31/4439;A61K31/454;A61K31/4545;A61K31/4725;A61K31/496;A61K31/497;A61K31/5377;A61K31/541;A61K31/55;A61K31/551;A61P1/04;A61P1/08;A61P1/12;A61P1/14;A61P3/04;A61P3/10;A61P9/00;A61P9/10;A61P11/06;A61P25/00;A61P25/02;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P27/06;A61P29/00;A61P31/04;A61P31/12;A61P35/00;A61P43/00;C07D231/06;C07D401/04;C07D401/12;C07D403/06;C07D403/12;C07D409/04 |
主分类号 |
A61K31/415 |
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