发明名称 |
DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE |
摘要 |
<p>The invention relates to compounds of a general formula (I):
wherein Ar 1 is an optionally-substituted aryl or heteroaromatic group; R 1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R 2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R 3 is a hydrogen atom or a lower alkyl group; R 4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of -N(R 1k )R 1m ; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.</p> |
申请公布号 |
CA2650119(A1) |
申请公布日期 |
2007.11.08 |
申请号 |
CA20072650119 |
申请日期 |
2007.04.25 |
申请人 |
BANYU PHARMACEUTICAL CO., LTD. |
发明人 |
HIRAI, HIROSHI;YAMAMOTO, FUYUKI;SUNAMI, SATOSHI;BAMBA, MAKOTO;NIIYAMA, KENJI;NISHIBATA, TOSHIHIDE;YOSHIZUMI, TAKASHI;GOTO, YASUHIRO;SAGARA, TAKESHI;FURUYAMA, HIDETOMO;SAKAMOTO, TOSHIHIRO;OTSUKI, SACHIE;TAKAHASHI, KEIJI |
分类号 |
C07D471/04;A61K31/519;A61K31/5377;A61K31/54;A61K31/551;A61P35/00;A61P43/00;C07D487/04 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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