发明名称 |
PREPARATION OF AUTOLOGOUS HAEMATOPOIETIC STEM CELLS, THE METHODS OF PRODUCTION, CYROPRESERVATION AND USE FOR THERAPY OF TRAUMATIC DISEASES OF THE CENTRAL NERVOUS SYSTEM |
摘要 |
The invention applies to the field of cell transplantology and neurology and can be used to treat wound dystrophy of the central nervous system. The main idea of the invention is a preparation of haematopoietic stem cells (HSC), which is autologous HSC extracted from patient's peripheral blood enriched with cells containing CD34 antigen, in the final concentration of (40-100)x10<SUP>6</SUP> cells/ml. Enriching the blood is performed using intermittent administration of the preparation of the granulocyte colony-stimulating factor (G-CSF) - for example, Neilogen in the glucose solution, according to a certain scheme. Also, the method of production, cryoconservation of the preparation and the method of treating traumatic diseases in the brain and spinal cord, using the new preparation. The developed system allows patients to be helped with neurological diseases efficiently and suffering minimum injuries.
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申请公布号 |
WO2006102933(A8) |
申请公布日期 |
2007.11.08 |
申请号 |
WO2005EP08527 |
申请日期 |
2005.08.05 |
申请人 |
MEDITECH INDUSTRIES LLC;BRYUKHOVETSKIY, ANDREI STEPANOVICH;MENTKEVICH, GEORGIY LUDOMIROVICH;MKHEIDZE, DEIMURI MELITONOVICH;YARYGIN, VLADIMIR NIKITICH;ZAITSEV, ANDREI YURYEVICH;PALUMBO, OLGA |
发明人 |
BRYUKHOVETSKIY, ANDREI STEPANOVICH;MENTKEVICH, GEORGIY LUDOMIROVICH;MKHEIDZE, DEIMURI MELITONOVICH;YARYGIN, VLADIMIR NIKITICH;ZAITSEV, ANDREI YURYEVICH;PALUMBO, OLGA |
分类号 |
C12N5/00;A61K35/14;A61P25/00;A61P25/28;C12N5/08 |
主分类号 |
C12N5/00 |
代理机构 |
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