SOLID SUPPORT REAGENTS FOR SYNTHESIS

摘要

A compound which can be attached to a solid support and used as a reagent for methods of solid phase synthesis has the following structure: (I) where Ri is selected from hydrogen and C₁-C₆ alkyl; R₂ is selected from hydrogen, hydroxy, and C₁-C₆ alkoxy, or together R₁ and R₂ form a single bond; R₃, R₄, R₅ and R₆ are the same or different from each other and each represents hydrogen, C₁-C₆ alkyl, and halogen, or together R₃ and R₄ with R₅ and R₆ form an aromatic ring, further wherein the aromatic ring is substituted with one or more X; X is selected from halogen, nitro, amino, and aminocarbonyl; s is 0, 1, 2, or 3, t is 0, 1, 2, or 3, wherein s + t =1; R₇ and R₈ are the same or different from each other and each represents hydroxy, halogen, hydrogen, C₁-C₆ alkoxy, oxyacyl, or together R₇ and R₈ form a carbonyl; Y is selected from a methylene or substituted methylene, nucleoside, nucleotide, protected nucleoside, protected nucleotide, C₁-C₆ aryl, arylalkyl, heteroalkyl, heterocycle, and heteroaryl; n is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; Z is selected from OR and NHR; R is selected from hydrogen, SiR^a,R^bR^c, CR^aR^b, R^c, heteroalkyl, and C₁-C₆ alkyl; R^a, R^b, and R^c are the same as or different from each other and each represents methyl, ethyl, i-propyl, t-butyl, phenyl or substituted phenyl.