MOLECULAR CHAPERONE EXPRESSION INDUCER

摘要

Disclosed is a pharmaceutical composition having an activity of inducing the expression of an endoplasmic reticulum chaperone, which can be used effectively for the prevention of the cell death caused by endoplasmic reticulum stress or for the prevention of occurrence or progression of a neurodegenerative disease or the amelioration of a neurodegenerative disease. The pharmaceutical composition comprises a compound represented by the formula (I), a pharmaceutically acceptable salt thereof, or a solvate of the compound or the salt, as an active ingredient. (I) wherein R<SUP>1</SUP> and R<SUP>2</SUP> independently represent a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a lower alkoxy group; Alk represents a lower alkylene chain; and X represents an oxygen atom or a sulfur atom.