UNIVERSAL DONOR CELLS

摘要

Genetically engineered cells are provided which can serve as universal donor cells in such applications as reconstruction of vascular linings or the administration of therapeutic agents. The cells include a DNA sequence which is expressed by the cell and which codes for a protein having complement inhibitory activity and which provides protection against complement-based lysis, i.e., hyperacute rejection. In addition, the cell's natural genome is change d so that proteins encoded by either the class II or both the class I and the class 11 major histocompatibility complex genes do not appear on the cell's surface. In this way, attack by T- cells is avoided. Optionally, the cells can include a self-destruction mechanism so that they can be removed from the host when no longer needed.