NEW PROCESS FOR PREPARING NORBENZOMORPHAN, AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY USEFUL BENZOMORPHAN DERIVATIVES, PARTICULARLY (-)-(1R,5S,2R)-3'-HYDROXY-2-(2-METHOXYPROPYL)-5,9,9-TRIMETHYL-6,7-BENZOMORPHAN

摘要

The present invention relates to a new process for preparing a norbenzomorphan derivative of general formula 1, <IMG> the central intermediate step in the preparation of pharmaceutically useful benzomorphan derivatives, especially (-) - (1R, 5S, 2"R) -3' -hydroxy-2- (2-methoxypropyl) -5, 9, 9- trimethyl-6, 7-benzomorphan or [(-) -(2R, 6S, 2' R) -3- (2- methoxypropyl)-6,11,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6- methano-benzo[.alpha.]oxacin-9-ol](BIII 277).