发明名称 |
TADG-15: an extracellular serine protease overexpressed in carcinomas |
摘要 |
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
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申请公布号 |
US7291462(B2) |
申请公布日期 |
2007.11.06 |
申请号 |
US20030600187 |
申请日期 |
2003.06.20 |
申请人 |
THE UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES |
发明人 |
O'BRIEN TIMOTHY J.;TANIMOTO HIROTOSHI |
分类号 |
C12Q1/68;A61K38/00;A61K39/00;C07K14/00;C12N9/64;C12N15/00;C12N15/09;C12N15/63;C12N15/70;C12N15/74;C12Q1/00;G01N21/00;G01N21/75;G01N33/48;G01N33/53;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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